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Background and Purpose: according to the studies that have been conducted so far, the corona virus has more severe clinical consequences in diabetic patients than in non-diabetic cases;Therefore, the present study was conducted with the aim of investigating the severity of the disease and mortality in patients infected with the Coronavirus between these 2 groups. Materials and Methods: In this cross-sectional-analytical study, the clinical records of 185 hospitalized patients with a positive laboratory diagnosis of Covid-19 were reviewed from February 14 to February 26, 2020. The patients were divided into 2 non-diabetic (95 people) and diabetic (90 people) groups, and their clinical symptoms and blood biochemical parameters were compared. Results: Based on the results, most of the patients were male and compared to non-diabetic patients, the diabetic group was significantly older (P=0.01). In this study, the disturbance in paraclinical factors such as d-dimer, BUN, VBG and lymphopenia in diabetic patients was significantly higher than in the control group, which indicates the need for more care in diabetic patients. Conclusion: it is suggested to follow health protocols for people with land diseases, be more careful., therefore, more extensive research with larger sample sizes is needed to achieve more accurate results. [ FROM AUTHOR] Copyright of Journal of Pharmaceutical Negative Results is the property of ResearchTrentz and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full . (Copyright applies to all s.)
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Introduction: It has been shown that thrombocytopenia, like coagulation disorders, are common complications of COVID-19, increasing the risk of thrombosis and bleeding, producing in patients symptoms such as hematomas, petechiae, equimosis and bleeding from natural cavities, which are usually related to the severity of thrombocytopenia. For this reason, the present research aimed to establish the relationship between thrombocytopenia and the probability of mortality with the SOFA, APACHE II and NEWS-2 scoring systems in patients with COVID-19 admitted to the Ambato General Hospital during the period June 2021-November 2021. Materials and Methods : For the development of the research, there was a sample of 216 hospitalized patients who met the inclusion criteria, where 156 patients were in the clinical unit and 60 patients in the intensive care unit. Ifit was a descriptive, retrospective and crosssectional study, in which data from hospitalized patients were collected through the internal results reporting system DATALAB, and the AS-400 medical system for the review of patients' medical records, in addition to finding the relationship that existed between the study variables, the statistical program SPSS 25 was used. Results and Conclusions : The results indicate that, in terms of the risk factors of the patients, it was found that 64.81% were male, 54.6% over 50 years, 43.1% of hospitalized patients did not present or did not know their pathological history. When analyzing the analytical data of thrombocytopenia it was found that 14.8% of pacientis the presented during hospitalization, finally when analyzing the relationship between thrombocytopenia and the scoring systems SOFA, APACHE II and NEWS-2, Chi-square values of 1.329;3.327;2.406 respectively were obtained, indicating that no This is a correlation between the variables. It was concluded that there is no statistically significant relationship between thrombocytopenia and scoring systems. Further analyses with a larger population and that they have all theparameters necessary for the calculation of scoring systems are recommended. [ FROM AUTHOR] Copyright of Journal of Pharmaceutical Negative Results is the property of ResearchTrentz and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full . (Copyright applies to all s.)
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Purpose: The purpose of this study is to explore the information-seeking behavior of Egyptian physicians serving in COVID-19 isolation hospitals. Design/methodology/approach: A sample of 91 physicians serving in Egyptian isolation hospitals answered the study questionnaire. Findings: Demographically, more than half of respondents were males. Over one-third of them are holding Doctor of Medicine (M.D), followed by one-third holding Master of Medicine (MMed). Respondents' age ranged from 30 to 60 years. Internal medicine is the most common specialty, accounting for nearly half of all physicians, followed by chest medicine and intensive care medicine. The information-seeking behavior of these three groups in their regular work is believed to be different, but since all of the participants are working in COVID-19 isolation hospitals, they should have the same information resources, Internet access and the same needs relevant to COVID-19 in order to make accurate clinical decisions. The physicians used traditional and electronic information sources to fulfill their information needs, the most important of which were to make a specific research, find an answer to a specific case, and deliver a medical lecture. Colleagues, coworkers, nurses and pharmacists were the most important channels pursued by Egyptian physicians to obtain information. Originality/value: This study is the first study that focuses on investigating the information-seeking behavior of Egyptian physicians serving in isolation hospitals. Any findings resulted from this study may serve as a noteworthy reference that may be useful to the Egyptian health sector, experts, researchers, as well as policymakers in establishing strategic decisions for making the understating much better. Peer review: The peer review history for this article is available at: https://publons.com/publon/10.1108/OIR-08-2020-0350 [ FROM AUTHOR] Copyright of Online Information Review is the property of Emerald Publishing Limited and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full . (Copyright applies to all s.)
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Objective: To assess the frequency and correlation of GI manifestations with outcomes in hospitalized patients suffering from COVID-19. Study Design: Retrospective Cohort study. Setting: Tertiary Care Hospital, Gujrat. Period: April 1st, 2020 to March 31st, 2021. Material & Methods: Medical records were collected retrospectively from six hundred eighty eight COVID-19 patients having complete charts. Among them male were 364 (52.91%). Incomplete charts were excluded from the study. Multivariate logistic regression analysis was used after adjusting for co-morbidities and clinical demographics. Results: Most of the patients with COVID-19 presented with cough (38.44%), dyspnea (37.53%), and fever (34.34%), while GI symptoms were noted in 25.92% of patients. Among them diarrhea was in 12.83%, nausea and vomiting in 10.53%, diminished hunger 9.32%, and abdominal discomfort 3.83%. Mortality, admission to ICU and need for intubation was more common among patients with diarrhea. (p = 0.006). Conclusion: Gastrointestinal (GI) manifestations are common in patients with COVID-19. Among them patients with diarrhea were more prone to admission to intensive care unit, intubation and death so patients with COVID-19 should be questioned for GI symptoms also. Medical professionals should know that diarrhea may be an indicator of severity of disease and its effect on prognosis of patient. [ABSTRACT FROM AUTHOR] Copyright of Professional Medical Journal is the property of Professional Medical Journal and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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Introduction: In patients with coronavirus disease 2019 (COVID-19), the prevalence of hyponatremia has been reported with varying outcomes. Objectives: The aim of this study was to evaluate the prevalence of hyponatremia in hospitalized patients with COVID-19. Patients and Methods: In this multicenter cross-sectional study, information about hospitalized patients with COVID-19 admitted between March 2020 and September 2020, including age, gender, and serum levels of sodium, creatinine, and potassium, as well as blood urea nitrogen (BUN), was analyzed, while P value level less than 0.05 was considered significant. Results: A total of 667 hospitalized patients with COVID-19 were enrolled in the study, of which 54.4% were male. The median age of patients was 63 years old. About 39.4% of patients had hyponatremia on admission day. More than 80% of patients had mild hyponatremia. The median age of the hyponatremia group was significantly higher than that of eunatremia group. Conclusion: Our data showed that hyponatremia is observed in hospitalized patients with COVID-19 and is often mild. [ FROM AUTHOR]
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The article reports that China's government abandoned its zero-COVID policy on a major departure from previous assertions, with tally includes hospitalized patients for whom COVID-19 was either the direct cause of death or a contributing factor, as reported by National Health Commission.
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Introduction: Coronavirus disease 2019 (COVID-19), the disease linked to severe acute respiratory syndrome coronavirus-2, is a widespread infectious disease. Coronaviruses cause multiple systemic infections, but neurological involvement has been reported very rarely. Materials and Methods: The present study is a single-centre prospective study conducted during the COVID-19 pandemic from November 2020 to April 2021, at Mogamedicity Superspeciality Hospital, Punjab, India. All COVID-19 patients with de novo neurologic manifestations were eligible to take part in the study. A total of 810 confirmed COVID-19 patients were enrolled for the study. Demographic features and initial clinical manifestations were noted, and patients were followed up during the hospital stay for the development of any new neurological signs and symptoms. For analytical purposes, neurological presentations were grouped into the central nervous system, peripheral nervous system and musculoskeletal system manifestations. Appropriate laboratory testing was employed as required on a case-to-case basis. Results: In this study, the mean age of the patients was 46.6 ± 15.5 years. Five hundred and fifty two (66.9%) patients were male, while 268 (33.1%) were female. Neurological illness was a primary manifestation in 48 (6%) cases. These included encephalopathy (n = 30), ischaemic stroke (n = 4), Guillain–Barre syndrome, (n = 2), facial nerve palsy (n = 4) and encephalitis (n = 1). The most common neurological symptoms were headache (284 [35%]) and hyposmia (78 [9.6%]), followed by encephalopathy (68 [8.3%]). More serious complications such as seizures (14 [0.7%]) and stroke (18 [2.2%]) were also seen. Conclusion: COVID-19 can present with a neurological illness, and we should remain vigilant to the possibility of neurological presentation of COVID-19 that can be thrombo-embolic, inflammatory or immune-mediated. [ FROM AUTHOR] Copyright of Advances in Human Biology is the property of Wolters Kluwer India Pvt Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full . (Copyright applies to all s.)
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FAST-Forward trial reported that five-fraction radiotherapy (5fx-RT) schedule with 26 Gy in adjuvant setting after breast-conserving surgery for early-breast cancer (BC) was non-inferior to the standard hypo-fx (SHfx) schedule with 40 Gy in 15fx in terms of local tumor control. Since the COVID-19 pandemic started RT expert groups encouraged professionals to implement hypo-fx schedules in order to decrease visits of patients to hospitals. The aim of this study is to help radiation oncologists choose the most suitable patients for 5fx-RT schedule according to anatomical features. Between March 2020 and December 2021, 239 patients suitable for 5fx-RT schedule were referred to our department. Prescribed RT dose was 26 Gy in 5fx to the whole breast plus a simultaneously integrated boost (SIB) up to 29 Gy to tumor bed if indicated. Patients were divided into 3 groups: Group A: Patients treated with 5fx-RT schedule that met all the FAST-Forward constraints for normal tissues;Group B: Patients treated with 5fx-RT schedule that slightly did not meet all constraints, Group C: Patients switched to SHfx schedule as they did not meet constraints in an acceptable way. For each patient, we draw an imaginary straight line connecting the medial and lateral borders of PTV in the axial slice of simulation CT where the longest anteroposterior diameter was found. From midpoint of this line, we measured the tangent distance to PTV margin and collected the data as medial-to-lateral tangent (MELT). Data was analyzed using statistical software. 150 patients were included in group A, 75 in group B and 14 in group C. The median MELT distance was: 1.91cm, 2.48cm and 3cm respectively. We found that the increase in MELT distance was significantly associated with a poorer compliance of normal tissue constraints (p<0.0001). Patient´s distribution among 3 groups for MELT distance intervals are shown in table 1. Median V8 for ipsilateral lung was: 13.1, 15.46 and 20.49% for groups A, B and C respectively. For the heart, median mean dose was: 1.06, 1.8 and 2.25 Gy for left breast cancer patients and 0.28, 0.33 and 0.48 Gy for right breast cancer patients for groups A, B and C respectively. We found a moderate positive correlation between MELT distance and dosimetric parameters assessed above (r=0.545, 0.475 and 0.418 respectively). According to laterality, for a higher MELT distance the % of left BC patients increased significantly (p=0.039). MELT distance is an easy tool that helps radiation oncologists predict which BC patients are the most suitable for 5fx-RT before RT planning begins. This could avoid delays in starting RT for patients with a high MELT distance directly planning them with the SHfx schedule. [ FROM AUTHOR] Copyright of International Journal of Radiation Oncology, Biology, Physics is the property of Pergamon Press - An Imprint of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full . (Copyright applies to all s.)
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Background: The recent worldwide pandemic of COVID-19 has been a serious, multidimensional problem that has left a detrimental worldwide impact on individuals of all ages and several organ systems. The typical manifestation of kidney involvement is acute kidney injury (AKI);however, there is a lack of consensus data regarding AKI epidemiology in COVID-19. Objective: The aim of the current work was to study the incidence and prognosis of acute kidney injury among patients hospitalized with COVID-19. Subjects and methods: This retrospective, observational cohort study was conducted on 163 COVID19 patients diagnosed by RT-PCR and carried in Inpatient and ICU of Geriatric Isolation Hospital, Ain Shams University hospitals for COVID19. Results: As regard predictors for AKI;each of presence of chronic kidney disease, mechanical ventilation, CRP > 74, and TLC >13 had high predictive value for occurrence of AKI among hospitalized COVID 19 patients. Conclusion: It could be concluded that AKI in COVID-19 patients is associated with a high mortality rate in ICUCOVID-19 patients. Our findings suggest that COVID-19 patients, particularly ICU COVID-19 patients, should be closely monitored for the development of AKI. Early identification of AKI, as well as prompt intervention, can improve COVID-19 patient outcomes. [ FROM AUTHOR] Copyright of Egyptian Journal of Hospital Medicine is the property of Egyptian Journal of Hospital Medicine and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full . (Copyright applies to all s.)
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Introduction: The Centers for Disease Control and Prevention has included asthma as a risk factor for developing severe coronavirus disease 2019 (COVID-19) illness. Respiratory viruses are known to run a more severe course in patients with underlying respiratory illnesses. However, the reports on the association of atopic dermatitis and COVID-19 infection are contrasting. Aims and Objectives: We aimed at assessing the difference between the severity of COVID-19 illness in patients having concurrent atopic dermatitis compared to those without concurrent atopic dermatitis. Materials and Methods: Study subjects included real-time polymerase chain reaction (RT-PCR) positive COVID-19 patients under the age of 18 years. The patients were divided into two groups, namely, cases and controls. Cases included children with atopic dermatitis diagnosed according to revised Hanifin and Rajka criteria with positive COVID-19 RT-PCR report. Controls were age-and sex-matched children from the same center with COVID-19, without atopic dermatitis. Disease severity was compared between the two groups. In addition, the COVID-19 severity was correlated with the SCORAD in the "cases" group. Results: While assessing the severity of COVID-19 illness on the basis of computed tomography score and clinical severity, there was a higher proportion of "severe" illness in "cases" compared to "controls," however, the difference was statistically insignificant. There was no significant correlation between high SCORAD scores and severe COVID-19 illness. Conclusion: Our study contributes to the ever-growing data suggesting that atopic diathesis is not a risk factor for acquiring COVID-19. [ FROM AUTHOR] Copyright of Indian Journal of Paediatric Dermatology is the property of Wolters Kluwer India Pvt Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full . (Copyright applies to all s.)
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BACKGROUND: There is a paucity of information about Brazilian COVID-19 in-hospital mortality probability of death combining risk factors. OBJECTIVE: We aimed to correlate COVID-19 Brazilian in-hospital patients' mortality to demographic aspects, biomarkers, tomographic, echocardiographic findings, and clinical events. METHODS: A prospective study, single tertiary center in Brazil, consecutive patients hospitalized with COVID-19. We analyzed the data from 111 patients from March to August 2020, performed a complete transthoracic echocardiogram, chest thoracic tomographic (CT) studies, collected biomarkers and correlated to in-hospital mortality. RESULTS: Mean age of the patients: 67 ± 17 years old, 65 (58.5%) men, 29 (26%) presented with systemic arterial hypertension, 18 (16%) with diabetes, 11 (9.9%) with chronic obstructive pulmonary disease. There was need for intubation and mechanical ventilation of 48 (43%) patients, death occurred in 21/111 (18.9%) patients. Multiple logistic regression models correlated variables with mortality: age (OR: 1.07; 95% CI 1.02-1.12; p: 0.012; age >74 YO AUC ROC curve: 0.725), intubation need (OR: 23.35; 95% CI 4.39-124.36; p < 0.001), D dimer (OR: 1.39; 95% CI 1.02-1.89; p: 0.036; value >1928.5 ug/L AUC ROC curve: 0.731), C-reactive protein (OR: 1.18; 95% CI 1.05-1.32; p < 0.005; value >29.35 mg/dl AUC ROC curve: 0.836). A risk score was created to predict intrahospital probability of death, by the equation: 3.6 (age >75 YO) + 66 (intubation need) + 28 (C-reactive protein >29) + 2.2 (D dimer >1900). CONCLUSIONS: A novel and original risk score were developed to predict the probability of death in Covid 19 in-hospital patients concerning combined risk factors.
Subject(s)
COVID-19 , Hospital Mortality , Aged , Aged, 80 and over , Biomarkers , Brazil/epidemiology , C-Reactive Protein , COVID-19/diagnosis , COVID-19/mortality , Female , Humans , Male , Middle Aged , Prognosis , Prospective Studies , ROC Curve , Retrospective Studies , Risk FactorsABSTRACT
B Conclusions: b Patients on RAAS inhibitors prior to hospitalization for SARS-CoV-2 infection had higher mortality and complications than those not on these medications. B Introduction: b The aim of our study was to determine the effect of prior use of renin-angiotensin-aldosterone system (RAAS) inhibitors on mortality and outcomes in hospitalized patients with laboratory-confirmed SARS-CoV-2 infection. [Extracted from the article] Copyright of Critical Care Medicine is the property of Lippincott Williams & Wilkins and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full . (Copyright applies to all s.)
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We grouped in-patients who had ICD-10 codes (F03.90/F01/G31.09) for dementia with age and gender (1:2) matched patients without a dementia diagnosis. In logistic regression analysis, dementia patients had no difference in mortality- OR= 1.0 (95% CI 0.86-1.17), but ICU admissions were significantly lower, OR= 0.58 (95% CI 0.51-0.66). B Conclusions: b Based on our findings, though dementia patients have higher unadjusted hospital mortality compared to non-dementia patients, in logistic regression analysis, there was no difference in hospital mortality. [Extracted from the article] Copyright of Critical Care Medicine is the property of Lippincott Williams & Wilkins and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full . (Copyright applies to all s.)
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B Introduction: b COVID-19 is an ongoing global pandemic that causes respiratory failure and ARDS. Of all patients that required high flow oxygen at any point during hospital admission (25), 76% (19) did not require mechanical ventilation, 44% did awake prone, 52% received steroids and 8% received tocilizumab before mechanical ventilation. Mortality rates were 12.5%, 15.7%, 62.5% and 37.1% for all patients, patients that required high flow oxygen as the highest level of respiratory support, patients that required mechanical ventilation as the highest level of respiratory support, and patients that required high flow oxygen or mechanical ventilation;respectively. [Extracted from the article] Copyright of Critical Care Medicine is the property of Lippincott Williams & Wilkins and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full . (Copyright applies to all s.)
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Background: Increasing numbers of people dying from COVID-19 are reported, but data are lacking on the way they die. Objective: To study symptoms and symptom relief during the last week of life, comparing nursing homes with hospitals. Design: The Swedish Register of Palliative Care with national coverage was used. Breakthrough symptoms were registered as Yes/No. Symptom relief was recorded on a 3-grade scale as complete-partial-no relief. All deaths in COVID-19 were contrasted to deaths in a reference population (deaths 2019). Deaths at nursing homes were compared with deaths in hospitals. Setting and Subjects: All deaths in hospitals or nursing homes (n = 490) were analyzed. Deaths in other settings (specialized palliative care wards [n = 11], in palliative home care [n = 2], or in their own homes [n = 8]) were excluded (n = 21). Only patients with expected deaths (n = 390) were entered in the final analysis. Results: Breathlessness as a breakthrough symptom was more common in COVID-19 patients than in the 2019 reference population (p < 0.001) and relief of breathlessness, as well as anxiety, delirium, and death rattles was less successful in COVID-19 patients (p < 0.05 to p < 0.01 in different comparisons). Patients were older in nursing homes than in hospitals (86.6 years vs. 80.9 years, p < 0.001) and more often female (48% vs. 34%, p < 0.001). Breakthrough of breathlessness was much more frequently reported in hospital settings than in nursing homes, 73% versus 35% (p < 0.0001), and complete relief was more rarely possible in hospitals, 20% versus 42% (p < 0.01). The proportion of partial relief+complete relief was comparable, 92% versus 95% (ns). Also, anxiety and pain were more often completely relieved in nursing homes (p < 0.01 in both comparisons). Conclusion: The lower symptom prevalence in nursing homes may be explained by elderly frail residents dying already in the first phase of the COVID-19 disease, before acute respiratory distress syndrome develops.